pI: 8.2548 |
Length (AA): 61 |
MW (Da): 6885 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 55 | 1okc (A) | 237 | 293 | 53.00 | 0.000000000018 | 0.11 | 1.24494 | 1.61 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Oocyst. | Fritz HM |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | VEG Tachyzoite. | Gregory |
Sibley/Greg | ToxoDB |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_126841)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G56450 | probable ADP,ATP carrier protein |
Arabidopsis thaliana | AT4G28390 | ADP/ATP carrier 3 protein |
Arabidopsis thaliana | AT3G08580 | ADP,ATP carrier protein 1 |
Arabidopsis thaliana | AT5G13490 | ADP/ATP carrier protein 2 |
Babesia bovis | BBOV_III010060 | adenine nucleotide translocase |
Brugia malayi | Bm1_42895 | ADP/ATP translocase |
Brugia malayi | Bm1_18515 | ADP,ATP carrier protein, heart/skeletal muscle isoform T1 |
Candida albicans | CaO19.8545 | similar to S. cerevisiae PET9 (YBL030C) mitochondrial inner membrane ATP/ADP translocator |
Candida albicans | CaO19.930 | similar to S. cerevisiae PET9 (YBL030C) mitochondrial inner membrane ATP/ADP translocator |
Caenorhabditis elegans | CELE_W02D3.6 | Protein ANT-1.2 |
Caenorhabditis elegans | CELE_T27E9.1 | Protein ANT-1.1, isoform B |
Caenorhabditis elegans | CELE_K01H12.2 | Protein ANT-1.3 |
Caenorhabditis elegans | CELE_T01B11.4 | Protein ANT-1.4 |
Cryptosporidium hominis | Chro.80141 | ADP/ATP carrier |
Cryptosporidium parvum | cgd8_1210 | mitochondrial ADP/ATP-transporter, integral membrane protein with 4 transmembrane domains |
Dictyostelium discoideum | DDB_G0267454 | ADP/ATP translocase |
Drosophila melanogaster | Dmel_CG1683 | Adenine nucleotide translocase 2 |
Drosophila melanogaster | Dmel_CG16944 | stress-sensitive B |
Echinococcus granulosus | EgrG_000610400 | atp:adp antiporter |
Echinococcus multilocularis | EmuJ_000610400 | atp:adp antiporter |
Homo sapiens | ENSG00000151475 | solute carrier family 25 (mitochondrial carrier |
Homo sapiens | 293 | solute carrier family 25 (mitochondrial carrier |
Homo sapiens | ENSG00000151729 | solute carrier family 25 (mitochondrial carrier |
Homo sapiens | ENSG00000005022 | solute carrier family 25 (mitochondrial carrier |
Leishmania braziliensis | LbrM.19.0520 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania braziliensis | LbrM.19.0510 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania donovani | LdBPK_190200.1 | ADP,ATP carrier protein 1, mitochondrial precursor, putative |
Leishmania infantum | LinJ.19.0200 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania infantum | LinJ.19.0190 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania major | LmjF.19.0200 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania major | LmjF.19.0210 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania mexicana | LmxM.19.0210 | ADP,ATP carrier protein 1, mitochondrial precursor, putative,ADP/ATP translocase 1, putative |
Leishmania mexicana | LmxM.19.0200 | ADP,ATP carrier protein 1, mitochondrial precursor, putative |
Loa Loa (eye worm) | LOAG_02370 | ADP/ATP translocase |
Loa Loa (eye worm) | LOAG_07239 | ADP/ATP carrier protein |
Mus musculus | 73333 | solute carrier family 25 (mitochondrial carrier |
Mus musculus | 11739 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 |
Mus musculus | ENSMUSG00000016319 | solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 |
Neospora caninum | NCLIV_060320 | mitochondrial carrier domain-containing protein, putative |
Neospora caninum | NCLIV_066020 | hypothetical protein |
Oryza sativa | 9270318 | Os05g0539600 |
Oryza sativa | 4338353 | Os05g0302700 |
Oryza sativa | 4330539 | Os02g0718900 |
Onchocerca volvulus | OVOC7706 | Putative adp,ATP carrier protein |
Onchocerca volvulus | OVOC9982 | Putative adp,ATP carrier protein |
Plasmodium berghei | PBANKA_0520200 | ADP/ATP transporter on adenylate translocase, putative |
Plasmodium falciparum | PF3D7_1037300 | ADP/ATP transporter on adenylate translocase |
Plasmodium knowlesi | PKNH_0621800 | ADP/ATP transporter on adenylate translocase, putative |
Plasmodium vivax | PVX_250300 | unspecified product |
Plasmodium vivax | PVX_110895 | ADP/ATP transporter on adenylate translocase, putative |
Plasmodium yoelii | PY03882 | adenine nucleotide translocase |
Saccharomyces cerevisiae | YBR085W | ADP/ATP carrier protein AAC3 |
Saccharomyces cerevisiae | YBL030C | ADP/ATP carrier protein PET9 |
Schistosoma japonicum | Sjp_0062310 | ko:K05863 solute carrier family 25 (mitochondrial carrier; adenine nucleotide, putative |
Schistosoma mansoni | Smp_079220 | ADPATP carrier protein |
Schmidtea mediterranea | mk4.002697.00 | Putative adp,ATP carrier protein |
Trypanosoma brucei gambiense | Tbg972.10.17990 | mitochondrial carrier protein, putative,ADP/ATP translocase 1, putative |
Trypanosoma brucei | Tb927.10.14820 | Mitochondrial ADP/ATP carrier protein 5c |
Trypanosoma brucei | Tb927.10.14840 | Mitochondrial ADP/ATP carrier protein 5a |
Trypanosoma brucei | Tb927.10.14830 | Mitochondrial ADP/ATP carrier protein 5b |
Trypanosoma congolense | TcIL3000_10_12690 | Mitochondrial ADP/ATP carrier protein 5c, putative |
Trypanosoma cruzi | TcCLB.506211.160 | Mitochondrial ADP/ATP carrier protein 5, putative |
Trypanosoma cruzi | TcCLB.511289.70 | Mitochondrial ADP/ATP carrier protein 5, putative |
Toxoplasma gondii | TGME49_300360 | ADP/ATP translocase |
Toxoplasma gondii | TGME49_249900 | adenine nucleotide translocator, putative |
Toxoplasma gondii | TGME49_237700 | ADP/ATP carrier protein, putative |
Theileria parva | TP02_0141 | adenine nucleotide translocase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14820 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14820 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14820 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14820 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T27E9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T27E9.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T27E9.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T27E9.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_K01H12.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K01H12.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K01H12.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K01H12.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K01H12.2 | Caenorhabditis elegans | sterile | wormbase |
CELE_T01B11.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T01B11.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T01B11.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T01B11.4 | Caenorhabditis elegans | sterile | wormbase |
YBL030C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0520200 | Plasmodium berghei | Slow | plasmo |
TGME49_237700 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_249900 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_300360 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_237700 this record | Toxoplasma gondii | Probably essential | sidik |
TGME49_249900 | Toxoplasma gondii | Probably essential | sidik |
TGME49_300360 | Toxoplasma gondii | Probably essential | sidik |
TGME49_237700 this record | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_249900 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_300360 | Toxoplasma gondii | Probably non-essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | solute carrier family 25 (mitochondrial carrier | Compounds | References |